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While today’s culture routinely misleads us into believing that money is the only key to happiness, the majority of us are aware that there are a plethora of other methods in which we might become prosperous. Our health becomes our number one concern as soon as we or someone close to us is afflicted with a disease or suffers a serious accident. The United States is fortunate in that we have access to a variety of pharmaceutical medications that may assist our bodies’ immune systems in fighting sickness and allowing us a greater chance of recovery when we are sick.
The United States has long been a pioneer in pharmaceutical research and development. Many bright scientific minds are attracted to the country to work at the forefront of pharmaceutical advancement and innovation. Because of state-of-the-art facilities, cutting-edge technology, and medical advances, we now have the information necessary to comprehend the underlying causes of many diseases, as well as the risk factors for certain populations. This gives the option for early detection and treatment of preventive conditions.
When it comes to pharmaceutical research and development, the problem is that it is a time-consuming and expensive endeavor. Pharmaceutical firms are obviously eager to devote the bulk of their budget to the development of drugs that will make a profit and provide a return on their substantial investment. However, this is not always possible. Consequently, corporate and government funds are necessary to stimulate the study of unproven procedures, the discovery of novel chemicals, and the development of drugs for illnesses that are less lucrative, such as those that affect uncommon or tropical diseases.
To bring a single successful chemical through the complete research and development process, it is projected that it will cost billions of dollars. That represents a significant financial burden before any patient or healthcare provider makes a purchase. The substance will be converted into a suitable liquid or solid dosage form when it has been determined as being effective. When it comes to the production of tablets and capsules, established methods such as pharmaceutical granulation, extrusion, and spheronization are utilized to combine active components with excipients in order to get the desired results.
The use of live testing throughout the development phase is one of the more contentious aspects of the process. Before a pharmaceutical product can be authorized, it must first go through a rigorous live testing process. While clinical trials on human volunteers are one of the last steps of this procedure, animal testing is often carried out at the beginning of the process before the start of the live studies.
Animal rights organizations have been protesting against this portion of the procedure for many years. According to one critic of the procedure’s usage, since animals and people are genetically distinct, there is no assurance that the human body would react similarly to the animal on whom the procedure was tried. Using human cell cultures as an alternative has been tried in the past, but since they have failed to match the intricacies of human organs, they have also failed to provide consistently accurate findings.
So, we all want to be able to access affordable and safe medications to cure our symptoms and aid in the battle against illness, but we don’t agree with the notion of animal testing being a part of the process. Is there a solution to this problem?
Design of the Year 2021
Awarded annually, Designs of the Year seeks to uncover a design that supports or delivers change, facilitates access to information, expands the scope of the design profession, or expresses the spirit of the times. According to the judges, this year’s award winners include a novel microprocessor that may hold the key to early-stage live testing in pharmaceutical development.
An entirely new kind of microchip has been invented to accurately duplicate the complete process of a certain organ, allowing it to respond in the most realistic way possible to the introduction of illness and medicinal chemicals. It replicates a natural interface by using cells from a particular organ in the body and cells from the blood vessel lining of the vessel. Additional parameters like blood flow and respiration may be duplicated on the microchip since these aspects have an impact on the outcomes. As a consequence, an artificial organ on a chip has been created. So far, lung, gut, and kidney chips have been developed and tested in clinical studies with great success.
The creation of human organ microchips offers the potential to speed up the development process, lower expenses, and minimize the need for animal testing, among other benefits. It might result in active compounds being recognized as safe for human ingestion more rapidly as a result of this.